Leveraging belonging in response to global loneliness

Global Surgery Priorities: A Response to Recent Commentaries

National and transnational belonging among Turkish and Moroccan older migrants in the Netherlands: protective against loneliness?

This research investigates how a sense of belonging functions as protective mechanism against loneliness. Inspired by the work of Berry (1980) on acculturation strategies (i.e. integration, assimilation, separation and marginalization), we distinguish migrants who feel a relatively strong or weak sense of belonging to larger society and those who feel a strong or weak belonging to the "own grou...

From Loss to Loneliness

Spousal bereavement can cause a rise in depressive symptoms. This study empirically evaluates 2 competing explanations concerning how this causal effect is brought about: (a) a traditional latent variable explanation, in which loss triggers depression which then leads to symptoms; and (b) a novel network explanation, in which bereavement directly affects particular depression symptoms which the...

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Lipopolysaccharides Lipopolysaccharides (LPS) are a major component of the cell surface of gram-negative bacteria and are typically thought to be a protective barrier against host defense molecules. Mutational analysis of a LPS biosynthesis gene (waaL) in Spiraeoideae-infecting strains of E. amylovora has shown LPS to be involved in virulence [1]. Comparison of the LPS biosynthetic gene cluster...

Leveraging the iron-starvation response to promote ferroptosis

An important micronutrient, iron is used by the cell either as an ion or upon assembly into heme or ironsulfur cluster (ISC) cofactors. Iron is generally not a free ion in the body, but is stored intracellularly by the protein ferritin and transported via association with transferrin. This iron sequestration is thought to occur because ironmediated lipid peroxidation via Fenton chemistry can re...